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KMID : 0387420200310010025
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Korean Society of Oriental Neuropsychiatry
2020 Volume.31 No. 1 p.25 ~ p.38
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A Review on Clinical Research Trend in Treatment of Chai-Hu-Shu-Gan-San (Sihosogan-San) for Insomnia
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Lee Jae-Eun
Kim Sang-Ho
Kim Bo-Kyung
Lim Jung-Hwa
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Abstract
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Objectives: This review aimed to investigate the effectiveness of Chai-Hu-Shu-Gan-San (CHSGS) for treatment of insomnia.
Methods: 9 databases were comprehensively searched from their inception dates until Jan 2020 using keywords like Insomnia, Chai-Hu-Shu-Gan-San and Sihosogan-san. We included randomized con-trolled trials (RCTs) using CHSGS as the main intervention for insomnia patients. We assessed the qual-ity of RCTs using the Cochrane risk of bias tool and Jadad scale.
Results: 5 RCTs were included. The Chinese classification of mental disorders -3 (CCMD-3) was the most frequently used diagnostic criteria. The effective rate was the most frequently used as outcome. All the 5 RCTs that reported CHSGS and CHSGS adjunctive therapy on insomnia were more effective compared to western medication. Only one study reported adverse effects. The methodological quality of the included RCTs were generally poor.
Conclusions: This review found that CHSGS may be effective to treating insomnia. However, because of the small number, heterogeneity and very low methodological quality of included studies, we could not draw any definitive conclusions. Therefore, more rigorous randomized control studies are warranted.
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KEYWORD
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Insomnia, Herbal medicine, Sihosogan-san, Chai-Hu-Shu-Gan-San
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